Molecular Genetics Additional Practice Test

12th Standard Zoology — Molecular Genetics: Additional Online Practice Test

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Who coined the term "gene" in 1909 to refer to the discrete determiners of inherited characteristics?

A.Wilhelm Johannsen B.Gregor Mendel C.Walter Sutton D.George Beadle

Which organism was used by George Beadle and Edward Tatum in the early 1940s to propose the one gene-one enzyme hypothesis?

A.Escherichia coli B.Neurospora crassa C.Streptococcus pneumoniae D.Drosophila melanogaster

In the transformation experiments of Avery, Macleod, and McCarty, the transforming ability of the heat-killed S-strain extract was lost only when treated with which enzyme?

A.Protease B.RNase C.DNase D.Amylase

Which radioactive isotopes were used by Alfred Hershey and Martha Chase in 1952 to selectively label viral proteins and DNA?

A.14C and 15N B.3H and 14C C.35S and 32P D.15N and 32P

What is the primary chemical difference between the pentose sugar ribose found in RNA and deoxyribose found in DNA?

A.Deoxyribose has one less carbon atom than ribose B.Deoxyribose has one less oxygen atom than ribose C.Deoxyribose has one more hydroxyl group than ribose D.Deoxyribose is a hexose sugar while ribose is a pentose sugar

A nucleoside is converted into a nucleotide when a phosphate group is covalently attached to which carbon of the pentose sugar?

A.1' carbon B.2' carbon C.3' carbon D.5' carbon

Who first coined and used the term "RNA world" in 1986 to hypothesize that RNA was the first genetic material on Earth?

A.Walter Gilbert B.Leslie Orgel C.Francis Crick D.Carl Woese

Approximately how many base pairs of DNA are wrapped around a single histone octamer to form a typical nucleosome in eukaryotes?

A.100 bp B.140 bp C.200 bp D.340 bp

The 30 nm chromatin fiber is stabilized by H1 interactions and forms a solenoid structure containing how many nucleosomes per turn?

A.Two nucleosomes B.Four nucleosomes C.Six nucleosomes D.Eight nucleosomes

Q10

Given that Escherichia coli has approximately 4.6 x 10^6 base pairs and replicates in 18 minutes, what is its average rate of polymerization?

A.500 bp/sec B.1000 bp/sec C.2000 bp/sec D.5000 bp/sec

Q11

In prokaryotes, which specific subunit of the RNA polymerase holoenzyme is responsible for recognizing the promoter sequence on DNA?

A.Alpha subunit B.Beta subunit C.Omega subunit D.Sigma subunit

Q12

What is the name of the AT-rich promoter region found in eukaryotes, which is also referred to as the Goldberg-Hogness box?

A.Pribnow box B.TATA box C.Shine-Dalgarno sequence D.Solenoid box

Q13

The point mutation causing sickle cell anemia involves a single base substitution in the sixth codon of the beta-globin gene, changing it from:

A.GTG to GAG B.GAG to GTG C.GUG to GAG D.GAG to GUG

Q14

What is the name of the prokaryotic ribosome binding site located at the 5' end of mRNA that base-pairs with 16S rRNA?

A.TATA box B.Pribnow box C.Shine-Dalgarno sequence D.Kozak sequence

Q15

Which is the largest known human gene, consisting of approximately 2.4 million bases?

A.Insulin B.Hemoglobin C.Dystrophin D.Actin

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About this Molecular Genetics test

This free online practice test covers Molecular Genetics from the 12th Standard Zoology (Samacheer Kalvi) syllabus. Choose the number of questions and an optional time limit, then answer and submit — everything is checked in your browser, with the correct answers and a worked explanation shown at the end. For the full solutions to every question in this set, see the solved MCQs page.

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